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KMID : 0389420130210020141
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Korean Journal of Stress Research
2013 Volume.21 No. 2 p.141 ~ p.149
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Treadmill Exercise Alleviates Traumatic Brain Injury-Induced Memory Impairment by Enhancing Cell Proliferation in the Hippocampus of Rats
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Kim Bo-Kyun
Shin Mal-Soon
Cho Jung-Wan
Lee Hee-Hyuk
Kim Chang-Ju
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Abstract
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Traumatic brain injury (TBI) induces many neuropsychiatric disorders, and memory loss is the most frequent symptom of TBI. In the present study, we investigated the effects of treadmill exercise on the short-term memory in relation with cell proliferation in the hippocampus following TBI in rats. The animals were randomly divided into four groups (N=10 in each group): sham-operation group, sham-operation and treadmill exercise group, TBI-induction group, and TBI-induction and treadmill exercise group. TBI was induced by an electromagnetic-controlled cortical impact. The animals in the treadmill exercise group were forced to run on the treadmill machine for 30 min once daily, for ten consecutive days. Induction of TBI deteriorated short-term memory and inhibited cell proliferation with suppressing brain-derived neurotrophic factor (BDNF) expression in the hippocampus. Treadmill exercise alleviated TBI-induced short-term memory impairment and also increased cell proliferation with enhancing BDNF expression in the hippocampus. The present results revealed that treadmill exercise overcame the TBI-induced memory impairment through enhancing cell proliferation in the hippocampus. Herein, we suggest that treadmill exercise may be used as the useful strategy for the functional recovery following traumatic brain damage
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KEYWORD
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Traumatic brain injury, Treadmill exercise, Short-term memory, Brain-derived neurotrophic factor, Rats
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